Endocrine Abstracts

Cardiovascular complications including arrhythmias and cardiac conduction disorders (ACCDs) are leading risk factors for high mortality rate in acromegaly. ACCDs are the main cause of sudden cardiac death in patients with acromegaly. These disorders are detected in up to 40% of patients. Different pathogenetic mechanisms contribute to the development of concentric biventricular myocardium hypertrophy which leads to electrophysiological myocardium feature changes. The goal of t...

In human adrenals, serotonin (5-HT), released by subcapsular mast cells, increases aldosterone secretion through activation of type 4 serotonin receptors (5-HT4R) but only exerts a modest control on cortisol production. Interestingly, illicit synthesis of 5-HT in adrenocortical cells as well as overexpression of the 5-HT4R and ectopic expression of the type 7 receptor (5-HT7R) have been observed in bilateral macronodular adrenal hyperplasia res...

Context: Primary aldosteronism (PA) is a common cause of secondary hypertension, and some PA adrenal tumors co-secrete glucocorticoids, causing subclinical or overt Cushing syndrome (CS). We recently reported correlations between hair cortisol concentration (HCC) and serum and urinary levels of cortisol in patients with CS.Objective: To determine correlations of segmental hair cortisol and biochemical markers of a referred cohort of patients for the eval...

Background: Cushing syndrome due to PPNAD is the main endocrine disorder of CNC, an autosomal dominant multiple neoplasia caused by germline inactivating mutations of the subunit type 1A (PRKAR1A) of the protein kinase A (PKA). In addition, germline inactivating mutations in the gene encoding phosphodiesterase 11A (PDE11A) have been identified in patients with PPNAD.Aim of the study: To investigate the role of PDE11A genetic alterati...

Introduction: We have previously identified (using a whole-genome large scale SNP- screening approach) germline inactivating stop codon mutations of the PDE11A4 in patients with Cushing syndrome due to micronodular adrenal hyperplasia. PDE11A4 is a cAMP/cGMP phosphodiesterase.Aim of the study: To investigate the role of PDE11A genetic alterations in a large cohort of ACT.Materials and methods: Leukocyte DNA from 117 adrenocortical ...

Context: Hypertension is one of the most preventable risk factors for cardiovascular disease and death. Up to 42.1% of non-Hispanic African-American subjects have hypertension. We recently found that germline ARMC5 variants may play a role in primary aldosteronism, particularly in African-Americans.Objective: We investigated a cohort of participants in the Minority Health Genomics and Translational Research Bio-Repository Database (MH-GRID) stud...

Background: The medullary thyroid carcinomas comprise 5-7% of all thyroid carcinomas. At the same time, they are responsible for up to 13% of all deaths of thyroid cancer.Incidence of sporadic medullary thyroid cancer in population 5-6 time higher in women, probably partially because women are likely to have thyroid nodules and undergo medical examination.Objective: The aim of the study is to determine how gender affects prognosis in patient...

Background: It is disputable whether to repeat FNAB after the first one was nondiagnostic, or to submit the patient to operation.Methods: Indication for FNAB was a thyroid nodule of ≥1 cm or of a less size with clinical or ultrasound features of malignancy. In case of multinodular goiter each nodule was punctured and examined separately.3929 cases (8%) were noninformative out of 49 419 FNAB of thyroid nodules performed in Nor...

Background: Fine needle aspiration biopsy is generally acknowledged as a «gold standard» for diagnostics of thyroid malignancies. However, data on FNAB vary considerably in publications from different centers. In this study we have analyzed the results of more than 40 000 FNAB of thyroid nodules performed in North-West Regional Endocrine Center during 2010–2012 years.Subjects and methods: Indication for FNAB was a thyroid nodule of ≥...

Background: Unintented parathyroidectomy during thyroid surgery – is one of typical complications, especially when an operation is augmented by lymphodissection. In this work, we present the results of calcium metabolism analysis in such patients.Subjects and methods: 3929 operations of patients with different thyroid diseases were performed during 2010–2012 years. 82 inadvertently excised parathyroid glands were revealed at histological examin...